Related Products of 20850-43-5, These common heterocyclic compound, 20850-43-5, name is 5-(Chloromethyl)benzo[d][1,3]dioxole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: Suspension of the appropriate 3-amino-1,1-dioxo-1,4,2-benzodithiazine derivative 4a-h (0.5 mmol), anhydrous K2CO3 (1.5 mmol, 0.21 g) and the appropriate alkyl chloride (0.6 mmol) in dry THF (5 ml) was heated at reflux for 20-24 h, then cooled in ice-bath and filtered off. The crude product was suspended in 5 ml of water, heated gently to ca. 50 C; and cooled with vigorous stirring until granular precipitate appeared. Filtering off and washing with cold water and diluted EtOH gave pure potassium salts. 4.5.6 ;N-{2-[(1,3-Benzodioxol-5-yl)methylthio]-4-chloro-5-[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]benzenesulfonyl}cyanamide potassium salt (5j) ;Starting from 4b (0.214 g) and 1,3-benzodioxol-5-ylmethyl chloride (0.102 g). Yield: 0.240 g (80%): m.p. 308-310 C; IR (KBr): nu 3436, 3086, 2924, 2172, 1602, 1585, 1543, 1502, 1486, 1327, 1289, 1253, 1141 cm-1; 1H NMR (500 MHz, DMSO-d6): delta 4.36 (s, 2H, SCH2), 6.01 (s, 2H, OCH2O), 6.88-7.04 (m, 5H, Ar), 7.68 (s, 1H, Ar), 7.70 (m, 2H, Ar), 8.08-8.09 (m, 2H, Ar), 8.47 (s, 1H, Ar); Anal. C23H13Cl2KN4O5S2 (C, H, N).
Statistics shows that 5-(Chloromethyl)benzo[d][1,3]dioxole is playing an increasingly important role. we look forward to future research findings about 20850-43-5.
Reference:
Article; Brozewicz, Kamil; Slawinski, Jaroslaw; European Journal of Medicinal Chemistry; vol. 55; (2012); p. 384 – 394;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics