Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 42265-67-8, name is 4-(tert-Butyl)-2-chloroaniline, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 42265-67-8
a) 4-t-Butyl-2-chloroaniline (30 g) was dissolved in dichloromethane (1.21) and the solution was cooled to -5 C. N-Chlorosuccinimide (21.7 g) was added portionwise to the vigorously stirred solution and stirring was continued for 1 h. Dimethyl sulfide (36 ml) was added to the solution (-5 C.) and stirring was continued for a further 1 h. The solution was then cooled to -65 C. and triethylamine (27 ml) was added. This solution was evaporated to half volume, washed successively with sodium hydroxide (1N), water and brine. The organic solution was dried (MgSO4) and evaporated in vacuo and the residue was purified on silica using hexane to 3% ether in hexane as eluent. This afforded 4-t-butyl-2-chloro-6-(methylthiomethyl)aniline (31.2 g) as a red oil. 1 H NMR (250 MHz, CDCl3) delta1.27 (9H, s, (CH3)3, 1.99 (3H, s, SCH3), 3.69 (2H, s, CH2 SCH3), 4.38 (2H, brs, NH2), 6.92 (1H, d, J=2.0 Hz, Ar–H), 7.21 (1H, d, J=2.0 Hz, ArH). m/z (CI+)=244 (M+ +1, 100%).
According to the analysis of related databases, 42265-67-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Merck Sharp & Dohme Ltd.; US5633281; (1997); A;,
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