Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1996-29-8, name is 1-Bromo-4-chloro-2-fluorobenzene, This compound has unique chemical properties. The synthetic route is as follows., category: chlorides-buliding-blocks
l-Bromo-4-chloro-2-fluorobenzene (20.51 g, 97.93 mmol) was stirred in THF under nitrogen and the r.m. cooled to -15 C. Isopropylmagnesium chloride (2 M in THF, 59.8 mL, 119.6 mmol) was added dropwise at -15 C. The r.m. was stirred at 0-5 C for 1 h, then cooled to -15 C. Intermediate 4 (10 g, 48.97 mmol) dissolved in THF (total amount of THF 120 mL) was added dropwise and the mixture was allowed to reach r.t. NH4C1 sat. sol. was then added dropwise and the r.m. extracted with DCM. The organic layer was dried over MgS04, filtered and concentrated in vacuo. The product was purified by flash column chromatography (silica, MeOH/DCM 0/100 to 4/96). The purest fractions were evaporated, yielding intermediate 49 (8.3 g, 51%).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1996-29-8.
Reference:
Patent; JANSSEN PHARMACEUTICA NV; VOS, Ann, Marleen; OEHLRICH, Daniel; GIJSEN, Henricus, Jacobus, Maria; WATTS, Karl, Shawn; BHAT, Sathesh, Pangala; VAN DEN KEYBUS, Frans, Alfons, Maria; (151 pag.)WO2018/162443; (2018); A1;,
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