Reference of 461432-23-5, A common heterocyclic compound, 461432-23-5, name is 4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene, molecular formula is C15H14BrClO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Boron tribromide (1.7 mL, 16.89 mmol) was added at 0 &Of dichloromethane (10 mL)Was slowly added dropwise to a solution of 2- (4-methoxyphenyl) -4-bromo-1-chlorobenzene 1f (5.0 g, 15.35 mmol, purchased from Shanghai Lu Lu Lan Co., Ltd.) in dichloromethane (50 mL) ,Rise to room temperature for 30 minutes.The pH was adjusted to 7 with saturated aqueous sodium bicarbonate solution,And then extracted with dichloromethane (50 mL x 2). The combined organic phases were washed with saturated brine (30 mL x 2), dried over anhydrous sodium sulfate, filtered and the filtrate was concentrated under reduced pressure.The title compound was obtained as a pale yellow solid (5.16 g, 100%). The crude product is used directly in the next step.
The synthetic route of 461432-23-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Gu Zheng; Wu Wuyong; Qu Tong; Tan Haoxiong; Kang Panpan; Deng Bingchu; (48 pag.)CN106892948; (2017); A;,
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