In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 14862-52-3 as follows. Quality Control of 3,5-Dibromochlorobenzene
Under an argon atmosphere, 1,3-dibromo-5-chlorobenzene (2.70 g, 10.0 mmol) was dissolved in THF (38 mL). The mixture was cooled to -15 C., a THF solution (0.86 M, 12.3 mL, 10.5 mmol) of isopropyl magnesium chloride / lithium chloride complex was added, and the temperature was raised to 0 C. over 3 hours. Cyanuric chloride (5.53 g, 30.0 mmol) was added to the reaction mixture at the same temperature, then the temperature was raised to room temperature and stirred for 24 hours. Saturated ammonium chloride aqueous solution was added to the reaction mixture to stop the reaction, and then ethyl acetate was added. The organic layer was separated and the aqueous layer was extracted twice with ethyl acetate. The organic layers were combined, washed with water and dried over sodium sulfate.After filtering off the solid, the low-boiling fraction was removed under reduced pressure and the resulting residue was dried under vacuum to give crude product (6.74 g). The obtained crude product (6.6 g) was heated to 40 C. for 4 hours under reduced pressure (8 Pa), then heated to 50 C. and heated for 12 hours. After cooling to room temperature, purification by silica gel chromatography (eluent: hexane / ethyl acetate) gave the desired 2- (3-bromo-5-chlorophenyl) -4,6- dichloro-1,3,5- Triazine (82%, 2.80 g, 8.2 mmol).
According to the analysis of related databases, 14862-52-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; TOSOH CORPORATION; SAGAMI CHEMICAL RESEARCH INSTITUTE; AIHARA, HIDENORI; SHONO, TOMOHIRO; (35 pag.)JP2017/160145; (2017); A;,
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