Synthetic Route of 19752-55-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 19752-55-7, name is 1-Bromo-3,5-dichlorobenzene belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
General procedure: 3,5-Dichloro-1-bromobenzene (7.46 g, 33.0 mmol) or 3,5-bis(trifluoromethyl)-1-bromobenzene (9.67 g, 33.0 mmol) was dissolved in ether (70 mL). To this solution, BuLi (1.58 M in hexane, 20.9 mL, 33.0 mmol) was added using syringe through septum cap at -78 °C for 20 min, and the mixture was stirred for 2 h at -78 °C. To the reaction mixture a solution of antimony (III) boromide (3.61 g, 10.0 mmol) in ether (50 mL) was added dropwise at -78 °C, and the resulting mixture was gradually raised to room temperature and stirred overnight. The reaction mixture was diluted with ether (150 mL) quenched with water. The mixture was extracted with ether (150 mL). The combined extracts were washed with brine and dried over anhydrous magnesium sulfate. The dried organic layer was concentrated under reduced pressure. The residue was purified on silica gel column chromatography to give 1n (hexane, 4.5 g, 80 percent yield) and 1o (hexane: CH2Cl2 4:1, 6.9 g, 91 percent yield).
The synthetic route of 1-Bromo-3,5-dichlorobenzene has been constantly updated, and we look forward to future research findings.
Reference:
Article; Yasuike, Shuji; Nakata, Kazuhide; Qin, Weiwei; Matsumura, Mio; Kakusawa, Naoki; Kurita, Jyoji; Journal of Organometallic Chemistry; vol. 788; (2015); p. 9 – 16;,
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