Synthetic Route of 203302-92-5, A common heterocyclic compound, 203302-92-5, name is 3-Bromo-2-chloro-6-fluorotoluene, molecular formula is C7H5BrClF, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
11. Reactions which are covered by Scheme 11; Example 11.1 : Preparation of (3-bromo-2-chloro-6-fluoro-phenyl)-acetic acid; Step 1; 3-Bromo-2-chloro-6-fluoro-toluene (8.0 g), N-bromosuccinimide (NBS) (6.42 g) and a catalytic amount of benzoyl peroxide in carbon tetrachloride (40 ml) were heated to reflux. A 500 watt tungsten halogen lamp was used to initiate the reaction. The reaction mixture was heated to reflux and irradiated for 30 minutes. The reaction mixture was allowed to cool and then filtered. The filtrate was concentrated to give a colourless oil which solidified on standing to give l-bromo-3-bromornethyl-2-chloro-4-fluorobenzene as an off-white solid (10.7 g). 1H NMR (CDCl3): 4.64 (d, 2H), 6.94 (t, IH), 7.58 (dd, IH) ppm.
The synthetic route of 203302-92-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SYNGENTA LIMITED; WO2008/9908; (2008); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics