Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 106131-61-7, name is 3,6-Dichloro-1,2,4,5-tetrazine, This compound has unique chemical properties. The synthetic route is as follows., Safety of 3,6-Dichloro-1,2,4,5-tetrazine
General procedure: In a 100 mL round bottom flask, was introduced the diol(0.66 mmol), s-collidine (0.79 mmol) and 20 mL of dry dichloromethane and the mixture was stirred at room temperature. 3,6-dichloro-s-tetrazine 1 (0.66 mmol) was dissolved in dry dichloromethane and added dropwise in the flask. After 2 h the reaction is complete (TLC) and the solvent was removed under reduced pressure. The crude residue was purified by column chromatography on silica gel (eluent from petroleum ether/ethyl acetate 7/3 to pure ethyl acetate). Compound 2a was isolated as pink solid in 58 % yield(0.22 g). M. p.: 131 C.1HNMR (400MHz, Acetone-d6): delta (ppm) 5.49 (t, 2H, 3JHF= 13.19Hz, (CF2)8CH2 – O); 4.18 (t, 2H, 3JH-F = 14.79 Hz,(CF2)8CH2 – OH). 13CNMR (100MHz, Acetone-d6): delta (ppm) 167.1 (CTz-O);166 (CTz-Cl); 100-120 ((CF2)8); 65.3 (t, 2JC-F = 26.83 Hz,(CF2)8CH2 – O); 60.4 (t, 2JC-F = 24.93Hz, (CF2)8CH2 – OH).19F NMR (376 MHz, Acetone-d6): delta (ppm) -119.93 (m,2F); -122.33 (m, 10F); -123.49 (m, 2F); -123.87 (m, 2F).
According to the analysis of related databases, 106131-61-7, the application of this compound in the production field has become more and more popular.
Reference:
Article; Guermazi, Refka; Royer, Lorna; Galmiche, Laurent; Clavier, Gilles; Audebert, Pierre; Hedhli, Ahmed; Journal of Fluorescence; vol. 26; 4; (2016); p. 1349 – 1356;,
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