Some common heterocyclic compound, 7006-52-2, name is N-Methyl-3-chloroaniline, molecular formula is C7H8ClN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of N-Methyl-3-chloroaniline
The suitable omega-bromoalkanoyl chloride (0.7 mmol) was added dropwise to a stirred ice-cooled solution of the suitable aniline (0.33 mmol) and NaHCO3 (0.10 g, 1.22 mmol) in EtOAc (0.4 mL) and water (0.4 mL), and the resulting mixture was stirred at room temperature for 20 min. Water was added and the aqueous phase was extracted three times with EtOAc. The combined organic phases were washed with brine, dried (Na2SO4) and concentrated under reduced pressure to afford a crude residue that was used for the next step, without further purification.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 7006-52-2, its application will become more common.
Reference:
Article; Spadoni, Gilberto; Bedini, Annalida; Bartolucci, Silvia; Pala, Daniele; Mor, Marco; Riccioni, Teresa; Borsini, Franco; Cabri, Walter; Celona, Diana; Marzi, Mauro; Tarzia, Giorgio; Rivara, Silvia; Minetti, Patrizia; European Journal of Medicinal Chemistry; vol. 80; (2014); p. 8 – 35;,
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