Reference of 2845-89-8, These common heterocyclic compound, 2845-89-8, name is 1-Chloro-3-methoxybenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Unless special limited, generally the reaction conditions are as follows: 110 C lower, aryl chloride (0.7mmol), the secondary amine (1.2equiv. , Relative to the aryl chloride), the tertiary butyl alcohol potassium (1.3equiv. , Relative to the aryl chloride), complex (41) (0.02 muM %) (40muL, complex (41) (9.7 mg) dissolved in 4.0 ml of 1, 4 – dioxane), 1, 4 – dioxane (1.0 ml) the reaction 24 hours. Yield rate of the product after separation and purification.
Statistics shows that 1-Chloro-3-methoxybenzene is playing an increasingly important role. we look forward to future research findings about 2845-89-8.
Reference:
Patent; Wenzhou University; Shao Lixiong; Lu Jianmei; Liu Feng; (23 pag.)CN106892945; (2017); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics