Related Products of 1996-29-8, These common heterocyclic compound, 1996-29-8, name is 1-Bromo-4-chloro-2-fluorobenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A solution of compound 40-a-1 (1 g, 4.77 mmol) in anhydrous tetrahydrofuran was added dropwise to a solutionof LDA (2M, 3 ml) in tetrahydrofuran at -50 C. After the addition was completed, the mixture was stirred for 30 minutesat -50 C. To the above reaction mixture was added methyl iodide (1037 mg, 7.30 mmol) at -50 C. The reaction mixturewas then allowed to naturally warm to room temperature, poured into water and extracted with ethyl acetate. The organicphase was washed with saturated brine, dried and concentrated, and the crude product was purified by column chromatography(100% petroleum ether) to give compound 40-a (747 mg) as a colorless oil, purity 77%, yield 70%, MSm/z(ESI):N/A
Statistics shows that 1-Bromo-4-chloro-2-fluorobenzene is playing an increasingly important role. we look forward to future research findings about 1996-29-8.
Reference:
Patent; Shanghai Haiyan Pharmaceutical Technology Co., Ltd.; Yangtze River Pharmaceutical Group Co., Ltd.; LAN, Jiong; ZHOU, Fusheng; ZHAO, Jinzhu; HUANG, Dong; XIE, Jing; HU, Yi; LV, Qiang; (63 pag.)EP3412653; (2018); A1;,
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