Reference of 7781-10-4,Some common heterocyclic compound, 7781-10-4, name is 4-Chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine, molecular formula is C7H6ClN3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A part of the resulted N-methylated compound (500 mg, 2.98 mmol) was dissolved in 5 ml abs. THF and cooled down to -78 C. Then 2M LDA (1.7 ml, 3.4 mmol) was added dropwise. The mixture was stirred at -78C for 1 hour, then iodide (757 mg, 2.98 mmol)was added. The solution was allowed to warm to r.t. and stirred for 22 hours, then 5 mlwater was added. Solid compound was formed and filtered off to give Preparation R2aj.HRMS calculated for C7H61N30: 274.9556; found 275.9634 [(M+H)+ form].1H-NMR(500 MHz, dmso-d6) oe ppm 11.97 (s, 1 H), 7.85 (s, 1 H), 6.79 (s, 1 H), 3.64 (s, 3H)13C-NMR(500 MHz, dmso-d6) oe ppm 157.3, 149.1, 144.2, 111.4, 110.3, 80.4, 33.2
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine, its application will become more common.
Reference:
Patent; LES LABORATOIRES SERVIER; VERNALIS (R&D) LIMITED; KOTSCHY, Andras; WEBER, Csaba; VASAS, Attila; MOLNAR, Balazs; KISS, Arpad; MACIAS, Alba; MURRAY, James Brooke; LEWKOWICZ, Elodie; GENESTE, Olivier; CHANRION, Maia; DEMARLES, Didier; (105 pag.)WO2017/212012; (2017); A1;,
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