Adding a certain compound to certain chemical reactions, such as: 461432-23-5, name is 4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 461432-23-5, Application In Synthesis of 4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene
Compound 3a (35.82 g, 110 mmol) and tetrahydrofuran (182 mL) were added to a three-necked flask and dissolved in an ice bath and cooled to -5 to 0C.A 2.0 M isopropyl magnesium chloride tetrahydrofuran solution (120 mmol, 60.0 mL) was added dropwise under a nitrogen atmosphere, and the reaction was maintained at an internal temperature of -5 to 0C for 1 hour.Compound 2a (36.34 g, 100 mmol) was dissolved in tetrahydrofuran (91 mL) under a nitrogen atmosphere, and slowly dropped into a reaction flask. After the dropwise addition, the temperature was raised to 25 to 30 C. and reacted for 2 to 3 hours.After the reaction was completed, the reaction was quenched by the addition of saturated ammonium chloride solution (182 mL), and the mixture was extracted twice with ethyl acetate (182 mL). The combined organic phases were washed twice with water (182 mL), dried over sodium sulfate, filtered, and concentrated with ethyl acetate. Recrystallization of ester and petroleum ether to give intermediate 4a(46.03g, 88%).
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Reference:
Patent; Hangzhou Kechao Biological Technology Co., Ltd.; Zheng Xuchun; Zhang Yiping; Xu Guanshu; (22 pag.)CN107540685; (2018); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics