Reference of 1008361-80-5, A common heterocyclic compound, 1008361-80-5, name is 4-Bromo-3-chlorobenzene-1,2-diamine, molecular formula is C6H6BrClN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of 4-bromo-3-chlorobenzene-l,2-diamine (0.1 g) in DMF (2 mL) at room temperature Iota, Gamma-carbonyldiimidazole (0.110 g) was added. The resulting homogeneous solution was stirred overnight at room temperature and then poured into 20 mL of water. The title compound was isolated by filtration, washed with water containing a few drops of 2 N aq. HC1 and dried under high vacuum.
The synthetic route of 1008361-80-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ACHILLION PHARMACEUTICALS, INC.; WILES, Jason, Allan; PHADKE, Avinash, S.; DESHPANDE, Milind; AGARWAL, Atul; CHEN, Dawei; GADHACHANDA, Venkat, Rao; HASHIMOTO, Akihiro; PAIS, Godwin; WANG, Qiuping; WANG, Xiangzhu; GREENLEE, William; (447 pag.)WO2017/35408; (2017); A1;,
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