Application of 24279-39-8, These common heterocyclic compound, 24279-39-8, name is 2,6-Dichloro-4-(trifluoromethyl)aniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Preparation 17; 2, 6-DICHLORO-4- (TRIFLUOROMETHYL) PHENYLDIAZONIUM TETRAFLUOROBORATE To a stired solution of 2,6-dichloro-4-(trifluoromethyl)aniline (11. 74 g, 0. 05 mol) in ethanol (12 ml) at -5C was added tetrafluoroboric acid (48% in water, 14 ml. 0.11 mol). A white precipitate formed accompanied by an increase in temperature to 5C. The reaction mixture WAS RECOOLED TO-5C. ISOAMYL nitrite (6.58 g, 56.1 mmol) was added dropwise over 5 min, the temperature rose to 3C. The reaction mixture was cooled TO-5C-AND stirred for 5 min before allowing to warm to ambient temperature for 30 min. The reaction mixture was filtered and the precipitate washed with absolute ethanol (11 ml) and diethyl ether (10 ML) to give Preparation 17 (14.91 g, 89%) as a crystalline solid. NMR (D20, selected data): 8. 3 (s, 2H).
The synthetic route of 24279-39-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PFIZER LIMITED; PFIZER INC.; WO2005/23773; (2005); A1;,
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