In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6579-54-0, name is 2,6-Dichlorobenzenesulfonyl chloride belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Product Details of 6579-54-0
171 mg 3-[6-(2-Methoxy-phenyl)-pyrimidin-4-ylamino]-benzyl-ammonium chloride (prepared in Example 69) (0.5 mmol) was dissolved in 50 cm3 dry dichloromethane, 0.350 cm3 N,N-diisopropyl- ethylamine (259 mg, 2 mmol) was added and the mixture was cooled to 0 C in an ice bath. After sirring it for 15 minutes 196 mg 2,6-dichlorobenzenesulfonyl-chloride (0.8 mmol) was added and the mixture was sirred for 2 hours at 0 C and overnight at room temperature. Then 50 cm3 5% NaHC03 solution was added and it was extracted three times with 50-50 cm3 of chloroform. The combined organic layer was washed with brine, dried over MgS04, decolorized with activated carbon and evaporated under reduced preasure. The residual solid was recrystallized from minimal amount of acetonitrile and air-dried to give the desired product as an yellow solid. Yield: 34 mg (13%). For analitical results and compound identification see Table 1.
The synthetic route of 6579-54-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; VICHEM CHEMIE KUTATO KFT.; GREFF, Zoltan; VARGA, Zoltan; KERI, Gyoergy; NEMETH, Gabor; OeRFI, Laszlo; SZANTAI KIS, Csaba; WO2011/77171; (2011); A1;,
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