These common heterocyclic compound, 698-01-1, name is 2-Chloro-N,N-dimethylaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 2-Chloro-N,N-dimethylaniline
General procedure: In to an oven-dried flask, N,N-dimethylaniline 1a(2.0 mmol), 1-(isocyanomethylsulfonyl)-4-methylbenzene 2a (1.0mmol), CuCl (0.2 mmol), PPh3 (0.4 mmol), SDS (0.5 mmol) and TBHP (70wt% aqueous, 2.7 mmol) were added at room temperature. In open air, water (5mL) was added and the reaction mixture was allowed to reaction at 70 oCfor 6 h. After the finish of the reaction, the mixture was filtered through apad of celite and the filtrate was extracted by EA three times. The combined organic layers was washed by brine and dried by Na2SO4. Afterthe removing of the organic solvents, the residue was then separated on a silica gel column and the final product was obtained as a yellow powder (174 mg, 52%).
The synthetic route of 2-Chloro-N,N-dimethylaniline has been constantly updated, and we look forward to future research findings.
Reference:
Article; Xie, Chunsong; Han, Laihong; Tetrahedron Letters; vol. 55; 1; (2014); p. 240 – 243;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics