Some common heterocyclic compound, 1435-48-9, name is 2,4-Dichloro-1-fluorobenzene, molecular formula is C6H3Cl2F, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 1435-48-9
In a 10001111 four-necked flask, 2,4-dichlorofluorobenzene was charged15 (^ (0.911111), cooling to 20 (: adding aluminum chloride 200. 2g (l.5mol), in the 20 ~ 30 CAdd acetyl chloride 78. 5g (l. Omol), 2 ~ 3h plus finished.Slowly heat up to 40 C and incubate for 30 min, then slowly heat up to 70 C and incubate for 1 ~ 2h, then slowly heat up to 110 C, 110 ± 2 CHeat 3 ~ 4h, cooling, add 500g 5% hydrochloric acid, hydrolysis at 80 ~ 90 C 2 ~ 3h, after washing to neutral, there areThe phase of the product was recrystallized from the second distillation to obtain 168 g of 2,4-dichloro-5-fluoroacetophenone in an amount of 99.8%. The yield was 89.3%
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1435-48-9, its application will become more common.
Reference:
Patent; Binhai Yongtai Medical Chemical Co Ltd; He, Renbao; Shao, Hongming; (8 pag.)CN102249881; (2016); B;,
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