Adding a certain compound to certain chemical reactions, such as: 61881-19-4, name is 2,2,2-Trifluoro-N-phenylacetimidoyl chloride, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 61881-19-4, SDS of cas: 61881-19-4
Disaccharide 92 (1.0 g, 1.03 mmol) was dissolved in a mixture of CH3CN/ /H20 (30 mL/7.5 mL). Ceric ammonium nitrate (1.69 g, 3.09 mmol) was added to the solution at 0 C and then the mixture was stirred at room temperature under N2 for 2 h. The mixture was concentrated to dryness and the residue was diluted with DCM (100 mL) and the organic phase was washed with H20 and then dried over Na2S04, filtered and the solvents were removed in vacuum. Silica gel column chromatography (3:2 hexanes-EtOAc) afforded the corresponding hemiacetal 93 (730 mg, 82%>). Compound 93, N-phenyltrifluoroacetimidoyl chloride (0.68 mL, 4.2 mmol) and DCM (50 mL) was cooled down to 0 C. DBU (127 mu, 0.95 mmol) was added and the mixture was stirred at room temperature for 1 h. The mixture was concentrated. Silica gel column chromatography (2: 1 hexanes-EtOAc) afforded the disaccharide donor 3 as a white solid (650 mg, 75%>).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2,2,2-Trifluoro-N-phenylacetimidoyl chloride, and friends who are interested can also refer to it.
Reference:
Patent; UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.; BOONS, Geert-Jan; WANG, Zhen; WO2012/135049; (2012); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics