51419-59-1, name is p-Tolylmethanesulfonyl chloride, belongs to chlorides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. COA of Formula: C8H9ClO2S
A solution of 1-(4-Amino-phenyl)-3-pyridin-4-ylmethyl-urea (80 mg, 0.33 mmol) in DIVIF (3 mL) was added p-Tolyl-methanesulfonyl chloride (94.7 mg, 0.46 mmol) and TEA (168.4 mg, 1.65 mmol). The reaction mixture was stirred at room temperature overnight. The mixture was washed H20 (10 mL) and extracted with EA (50 mL). The combined organic phase was dried over Na2SO4, filtered and concentrated. The residue was purified by prep-HPLC (5-95; NH4HCO3) to give n- [4-(3 -pyridin-4-ylmethyl-ureido)-phenyl] -c-p-tolyl-methanesulfonamide (35 mg, yield 26percent) as a white solid. ?H NMR (400 IVIHz, DMSO-d6): oe = 9.49 (s, 1H), 8.68 (s, 1H), 8.51-8.49 (m, 2H), 7.37 (d, J 8.8 Hz, 2H), 7.28 (d, J 5.6 Hz, 2H), 7.18-7.13 (m, 4H), 7.08 (d, J= 8.8 Hz, 2H), 6.71 (t, J= 5.6 Hz, 1H), 4.32 (d, J 5.6 Hz, 2H), 4.29 (s, 2H), 2.29 (s, 3H). MS: m/z 410.9 (M+HH).
The synthetic route of 51419-59-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; GARDELL, Stephen; PINKERTON, Anthony B.; SERGIENKO, Eduard; SESSIONS, Hampton; (428 pag.)WO2018/132372; (2018); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics