Reference of 33406-96-1, A common heterocyclic compound, 33406-96-1, name is 1-Chloro-4-fluoro-2-methylbenzene, molecular formula is C7H6ClF, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A mixture of aryl chloride (0.125 mmol), aryl boronic acid (0.15 mmol) and K4PO3 (0.25 mmol), catalyst (0.000125 mmol) in H2O (0.1 mL), isopropanol (0.1 mL) was stirred in a test tube at 45 C. After the reaction was completed, cooled to room temperature and the mixture was extracted with CH2Cl2 and dried over Na2SO4. The solvent was removed under vacuum. The product was purified by flash chromatography on a silica gel column. The characterization of all coupling products see Supporting Information.
The synthetic route of 33406-96-1 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Han, Fangwai; Li, Yanji; Liu, Guiyan; Lu, Qingwen; Ni, Chang; Zeng, Yongfei; Zhang, Rong; Zhang, Xue; Zhang, Yingying; Zhao, Yuxuan; Tetrahedron Letters; (2019);,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics