Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1939-99-7, name is Phenylmethanesulfonyl chloride, This compound has unique chemical properties. The synthetic route is as follows., name: Phenylmethanesulfonyl chloride
Step 1 : N-re^butyl-1 -phenylmethanesulfonamide To a solution of teri-butylamine (2 g, 27.3 mmol) in dichloromethane (90 mL) was added N,N-diisopropylethylamine (5.7 mL, 32.8 mmol), followed by phenylmethanesulfonyl chloride (6.25 g, 32.8 mmol) and the reaction was stirred at ambient temperature for 16 hours. The reaction was then diluted with dichloromethane, washed with water and brine, dried with MgS04, and purified by silica gel column chromatography (0-50% EtOAc in heptane) to give N-teri-butyl-l-phenyl- methanesulfonamide (4.81 g, 77% yield). 1 H NMR (400 MHz, CDC13) delta 7.51 – 7.44 (m, 2H), 7.41 (dd, J= 4.9, 2.0 Hz, 3H), 4.49 (s, 2H), 4.27 (s, 1H), 1.68 (s, 6H); LCMS (m/z) ES+ 228 [M+l]+.
According to the analysis of related databases, 1939-99-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; FAUBER, Benjamin; RENE, Olivier; WO2013/92941; (2013); A1;,
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