In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1996-29-8 as follows. Safety of 1-Bromo-4-chloro-2-fluorobenzene
To a solution of 1-bromo-4-chloro-2-fluorobenzene (10.0 g, 47.8 mmol) in dry THF (300 ml.) at -78 C under nitrogen was added LDA (2.0 M solution in THF, 31 ml_, 62.1 mmol) dropwise and the mixture was stirred at -78 C for 15 min. DMF (7.00 g, 95.8 mmol) was added and the mixture was allowed to warm to room temperature. The reaction mixture was quenched with a saturated aqueous NH4CI solution and the mixture was extracted with EtOAc (400 ml. x 3). The combined organic extracts were washed with brine (300 ml_), dried over Na2S04, filtered and concentrated under reduced pressure. The residue was purified by silica gel chromatography (100% Pet. Ether) to give the title compound (4.0 g, 35%) as a white solid, which was used directly in the next step.
According to the analysis of related databases, 1996-29-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; CTXT PTY LIMITED; MORROW, Benjamin, Joseph; CAMERINO, Michelle, Ang; WALKER, Scott, Raymond; STEVENSON, Graeme, Irvine; STUPPLE, Paul, Anthony; (266 pag.)WO2019/219820; (2019); A1;,
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