Electric Literature of 210532-25-5, These common heterocyclic compound, 210532-25-5, name is 3,5-Difluorobenzene-1-sulfonyl chloride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: Preparation of target compounds 3a-k: Intermediate 2 (0.1 g)and arylsulfonyl chloride (1 equiv) were dissolved in 3 mL dry pyridineat 0 C, and the reaction mixture was stirred overnight atroom temperature. The reaction was quenched by adding waterand acidifying the solution with 3 mL concentrated HCl. The productwas filtered and washed with water, or was extracted withethyl acetate and dried over Na2SO4, and the solvent was evaporated.If needed, further purification was achieved by recrystallizationfrom absolute methanol, affording target compounds 3a-k.
The synthetic route of 210532-25-5 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Huang, Boshi; Wang, Xueshun; Liu, Xinhao; Chen, Zihui; Li, Wanzhuo; Sun, Songkai; Liu, Huiqing; Daelemans, Dirk; De Clercq, Erik; Pannecouque, Christophe; Zhan, Peng; Liu, Xinyong; Bioorganic and Medicinal Chemistry; vol. 25; 16; (2017); p. 4397 – 4406;,
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