Application of 1127-85-1, These common heterocyclic compound, 1127-85-1, name is 2,4-Dichloro-5,6,7,8-tetrahydroquinazoline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
The title compound in this step was prepared according to the method described in step 4 of Example 4, ie, 2,4_dichloro_5,6,7,8-tetrahydroquinazoline (3.21 g, 15.8 lmmo 1) and sodium hydroxide solution (100mL, 1mol/L) and tetrahydrofuran (12mL)Reaction at 60C for 12h. The obtained crude product was separated and purified by silica gel column chromatography (petroleum ether/ethyl acetate (nu/nu) = 4/1) to obtain the standardThe title compound (white solid, 2.61g, 91%).
Statistics shows that 2,4-Dichloro-5,6,7,8-tetrahydroquinazoline is playing an increasingly important role. we look forward to future research findings about 1127-85-1.
Reference:
Patent; GUANGDONG HEC PHARMACEUTICAL; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; JIN CHUANFEI; Jin Chuanfei; LAO JINHUA; Lao Jinhua; ZHANG YINGJUN; Zhang Yingjun; (35 pag.)CN108299437; (2018); A;,
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