Application of 202197-26-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 202197-26-0 name is 3-Chloro-4-((3-fluorobenzyl)oxy)aniline, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
3-Chloro-4-((3-fluorobenzyl)oxy)aniline (12.58 g, 50 mmol) was added to 100 ml of toluene and stirred well.Thereafter, 0.4 g of acetic acid (as a catalyst) was added, followed by dropwise addition of triethyl orthoformate (3.8 g, at room temperature using an addition funnel.25 mmol), after the addition of the Dean-Stark apparatus, the reaction mixture was placed in an oil bath and heated to 80 C for 1 h.The ethanol was collected by a Dean-Stark apparatus; then the temperature was raised to 110 C for 2 h, and after the reaction was completed, it was cooled to room temperature and placed in an ice bath.The solid was precipitated, filtered, and the filter cake was washed with a little toluene to give (E)-N’-(3-chloro-4-((3-chlorobenzyl)oxy)phenyl)-N-(3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)carboxamidine 12.4 g, yield 93.7%. The HPLC purity was 99.14%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Chloro-4-((3-fluorobenzyl)oxy)aniline, and friends who are interested can also refer to it.
Reference:
Patent; Yancheng Normal College; Nanjing University Of Technology Dafeng Ocean Industrial Institute; Sun Yaquan; Zong Chaoyang; Gu Huiwen; (10 pag.)CN108440420; (2018); A;,
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