Synthetic Route of 41965-95-1, The chemical industry reduces the impact on the environment during synthesis 41965-95-1, name is 3-Chloro-4-methoxybenzylamine Hydrochloride, I believe this compound will play a more active role in future production and life.
Methyl 2-ch]oro^-[(3-chloro^-methoxybenzyi)amino]-6-cyanoquinoime-3- carboxylate, 14 [00171] To a heterogenous mixture of quinoline 13 (3.56 mmol) and 3-chloro-4-methoxy benzylamine-HCl (3.92 mmol) in NMP (15 mL) was added ‘Pr2NEt (8.90 mmol). The reaction mixture was heated to 80 C for 3 h. Subsequently, cooled the reaction mixture to ambient temperature and added 1M aqueous HC1 and EtOAc. The resulting layers were separated and the organic layer washed with water (3x) followed by brine (lx). The combined organic layers were dried over Na2S04, filtered, and concentrated in vacuo. The residue was dissolved in a minimum amount of hot EtOAc and allowed to cool to ambient temperature. Hexanes was then added to the solution and the intermediate 14 (80% yield) precipitated out and was collected by vacuum filtration. lU NMR (300 MHz, CDCI3) delta 8.20 (s, I I I ). 7.95 (d, i Pi. ./ 8.4 Hz), 7.82 (d, 1 1 1. 7 5 Hz), 7.38 (s, 1 H), 7.27-7.22 (m, 1H), 6.98 (d, 1 H, J=8.4 Hz), 6.26 is, 1H), 4.54 id, 2H J=4.8 Hz), 3.95 (s, 3H), 3.93 (s, 3H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Chloro-4-methoxybenzylamine Hydrochloride, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; LANDRY, Donald, W.; DENG, Shixian; FIORITO, Jole; ARANCIO, Ottavio; WASMUTH, Andrew; WO2015/9930; (2015); A2;,
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