Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 94-97-3, name is 5-Chloro-1H-benzo[d][1,2,3]triazole, A new synthetic method of this compound is introduced below., COA of Formula: C6H4ClN3
4-Nitro-5-chloro-1H-benzotriazole [22] 5-Chloro-1H-benzotriazole (3.08g, 20mmol) was dissolved in conc. sulphuric acid (40ml) and cooled to 0C on an ice bath. Nitric acid (40ml, excess) was added drop wise to the cooled solution over a period of 20 minutes. Stirring was continued for 1 hour at 0C and then at 60C for an additional 1 hour, by which time TLC (A) indicated the conversion of starting material. The solution was cooled to room temperature and poured over ice to precipitate a white solid. The solid was collected by filtration and washed with copious amounts of water until neutral to afford [22] in 83% yield. Rf(A) 0.49 deltaH(400MHz; DMSO-d6) 7.75 (1H, d, J8.8, BT) 8.38 (1H, br s, BT); m/z (EI-HR) 197.99383 [(M) calc. for C6H3N4O235Cl 197.99445] and 199.99345 [(M) calc. for C6H3N4O2 37Cl 199.99150].
The synthetic route of 94-97-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; University of Strathclyde; EP1272827; (2008); B1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics