Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 19752-55-7, name is 1-Bromo-3,5-dichlorobenzene, A new synthetic method of this compound is introduced below., Product Details of 19752-55-7
Xphos 42.80mg, at the same time added to a dry 25ml eggplant, and dissolved with toluene, stir. among them,The catalyst was 2.5percent mol of reactant 1 and the ligand was 10percent mol of reactant 1; the catalyst and ligand MoThe ratio is 1: 4.Next, 205.4 mg of 3,5-dichloro-1-bromobenzene (Reactant 1) was added to the bottle at 35 ° C,Continue stirring 3min. Then, 293.95 mg of tris (trimethylsilyl) yttrium (reactant 2) was dissolved with toluene,To obtain a concentration of 0.5mol / L solution, and the solution was added dropwise to the reaction solution by syringe, dropping timeFor 1h. After the addition was completed, continue to react 1h. Among them, tris (trimethylsilyl) yttrium and 3,5-dichloro-1-Bromobenzene molar ratio of 2: 5.Finally, the product was isolated and purified by column chromatography to give the product as a yellow liquid1- (trimethylsilyl)Methyl) -3,5-dichlorobenzene 6A, mass 152.68 mg, 72percent yield, conversion up to 100percent. among themThe eluant used for the column chromatography was a mixed solution of petroleum ether and ethyl acetate, and the molar ratio of petroleum ether and ethyl acetateThe ratio is 1: 0.1.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Beijing Institute of Technology; Li Xiaofang; Cai Guilong; Zhou Yuening; He Jianyun; Huang Yingda; (37 pag.)CN104496736; (2016); B;,
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