Electric Literature of 20850-43-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 20850-43-5, name is 5-(Chloromethyl)benzo[d][1,3]dioxole belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
5- (chloromethyl) prepared in Step 1 of Example 31 under an argon atmosphere benzo [d] [1,3] dioxole (2.29 g, 13.42 mmol)Was dissolved in acetonitrile (27 mL) The N- bromo succinimide polyimide (2.39 g, 16.11 mmol) was dissolved inRespectively. The reaction solution was stirred at room temperature for 13 hours,The completion of the reaction was monitored by TLC (hexane:Ethyl acetate = 2: 1).The reaction mixture was poured into water,The organic solvent layer extracted with dichloromethane (10 mL x 3) was washed again with a saturated solution of sodium chloride (50 mL), and the organic solvent layer was dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to remove the solvent. The concentrate was separated and purified by column chromatography (hexane: ethyl acetate = 5: 1) to obtain the desired compound (3.32 g, 99% yield).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-(Chloromethyl)benzo[d][1,3]dioxole, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Korea Institute of Science and Technology; Kim Eun-gyeong; Keum Gyo-chang; Lee Ju-hyeon; Shin Sang-cheol; Seo Seon-hui; (39 pag.)KR2018/40037; (2018); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics