These common heterocyclic compound, 13526-66-4, name is 3-Bromo-6-chloroimidazo[1,2-b]pyridazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 3-Bromo-6-chloroimidazo[1,2-b]pyridazine
In an inert atmosphere, 506 mg (2.2 mmol) of intermediate 1 , 1 g (2.3 mmol) of the crude 2-stannylbenzofurane, 41 mg (0.22 mmol) copper (.) iodide and 76 mg (0.1 1 mmol) bis(triphenylphosphine) palladium(ll)chloride in 18 mL of THF is stirred over night at 85 C in a sealed pressure tube. The solvent was evaporated, the obtained solid was digested in methanol and filtered off. The solid remainder was subjected to flash chromatography to yield 282 mg (39%) of the title compound as solid material. 1H-NMR (400 MHz, DMSO-d6), delta [ppm]= 3.99 (3H), 7.02 (1 H), 7.23 (1 H), 7.35 (1 H), 7.55 (1 H), 7.62 (1 H), 8.37-8.43 (6H).LCMS (Method 1 ): R, = 1 .29 min; MS (ESIpos) m/z = 300 [ +H]
The synthetic route of 3-Bromo-6-chloroimidazo[1,2-b]pyridazine has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BAYER INTELLECTUAL PROPERTY GMBH; KNUT, Eis; PUeHLER, Florian; ZORN, Ludwig; SCHOLZ, Arne; LIENAU, Philip; GNOTH, Mark; BOeMER, Ulf; GUeNTHER, Judith; FANGHAeNEL, Joerg; KORR, Daniel; WO2012/163942; (2012); A1;,
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