Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 39226-96-5, name is (2-Chloro-3-(trifluoromethyl)phenyl)methanamine, This compound has unique chemical properties. The synthetic route is as follows., Safety of (2-Chloro-3-(trifluoromethyl)phenyl)methanamine
Example 51 N-{[2-Chloro-3-(trifluoromethyl)phenyl]methyl}-3-methyl-2-oxo-1-[4- (trifluoromethyl)-2-pyrimidinyl]-4-imidazolidinecarboxamide (E51) (in a form obtainable or prepared from (4S)-2-oxo-3-{[(phenylmethyl)oxy]carbonyl}-4- imidazolidinecarboxylic acid); A mixture of crude 3-methyl-2-oxo-1-[4-(trifluoromethyl)-2-pyrimidinyl]-4- imidazolidinecarboxylic acid (10 ml of 0.05M solution in DCM, 0.5 mmol), N- ethylmorpholine (0.383 ml, 3.00 mmol), 1-hydroxybenzotriazole hydrate (92 mg, 0.600 mmol) and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (115 mg, 0.600 mmol) was stirred at room temperature for 10 minutes. A solution of {[2- chloro-3-(trifluoromethyl)phenyl]methyl}amine (105 mg, 0.5 mmol) in dichloromethane (1 ml) was added and the reaction stirred at room temperature for 18 hours. The reaction mixture was diluted with dichloromethane and the solution was washed with saturated sodium hydrogen carbonate solution, water, aqueous citric acid, water and brine, dried and evaporated. The residue was purified by silica gel chromatography eluting with 0-10% methanol in dichloromethane. The residue was triturated with ether and the resulting solid was collected and dried to give N-{[2- chloro-3-(trifluoromethyl)phenyl]methyl}-3-methyl-2-oxo-1-[4-(trifluoromethyl)-2- pyrimidinyl]-4-imidazolidinecarboxamide (150 mg, 62%). LC/MS [M+H]+ = 482, retention time 2.81 minutes.
According to the analysis of related databases, 39226-96-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GLAXO GROUP LIMITED; WO2008/119825; (2008); A2;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics