Synthetic Route of 870-24-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 870-24-6, name is 2-Chloroethanamine hydrochloride belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
A stirred solution of 2-chloroethylamine hydrochloride (l.OOg, 8.62mmol) and Et3N (3.60ml, 25.9mmol) in dry DCM (25ml) at 0C was treated with a solution of nosyl chloride (1.91g, 8.62mmol) in dry DCM (25ml) dropwise. On complete addition, the solution was warmed to ambient temperature and stirred overnight. The solution was evaporated and the residue purified by column chromatography (Si02, 20% EtOAc to 30% EtOAc in cyclohexane) to afford the title compound as a white solid (2.03g, 89%). XH NM (400 MHz, DMSO-d6) delta 8.45 – 8.38 (m, 3H), 8.09 – 8.04 (m, 2H), 3.59 (t, J = 6.0 Hz, 2H), 3.17 (s, 2H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Chloroethanamine hydrochloride, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; AB SCIENCE; BENJAHAD, Abdellah; MARTIN, Jason; SCHALON, Claire; PEZ, Didier; CHEVENIER, Emmanuel; SANDRINELLI, Franck; PICOUL, Willy; MOUSSY, Alain; WO2015/144614; (2015); A1;,
Chloride – Wikipedia,
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