Related Products of 61881-19-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 61881-19-4 name is 2,2,2-Trifluoro-N-phenylacetimidoyl chloride, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
3.1.16 Methyl 4-O-acetyl-2,3-di-O-benzyl-alpha-d-galactopyranosyluronate-(1?2)-3,4-di-O-benzyl-alpha-l-rhamnopyranosyl 1-N-phenyltrifluoroacetimidate (26) To a solution of 25 (261 mg, 0.33 mmol) in dry THF/MeOH (5.0 mL/5.0 mL), PdCl2 (28 mg, 0.16 mmol) was added. After being stirred at room temperature for 5 h, the solution was filtered through Celite and concentrated under vacuum. The resulting syrup was purified by chromatography on silica gel (petroleum ether/ethyl acetate, 2.5:1) to provide the hemiacetal as a colorless syrup (236 mg, 95%). To a solution of the hemiacetal (216 mg, 0.28 mmol) in acetone (2.5 mL), K2CO3 (116 mg, 0.84 mmol), and N-phenyl trifluoroacetimidoyl chloride (118 mg, 0.56 mmol) were added. After stirring at ambient temperature for 4 h, the mixture was filtered and concentrated in vacuo. The resulting residue was purified by column chromatography on silica gel (petroleum ether/ethyl acetate, 6:1) to afford 26 (242 mg, 92%), which was used directly without characterization.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2,2,2-Trifluoro-N-phenylacetimidoyl chloride, and friends who are interested can also refer to it.
Reference:
Article; Ma, Yuyong; Cao, Xin; Yu, Biao; Carbohydrate Research; vol. 377; (2013); p. 63 – 74;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics