Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 102-49-8, name is 3,4-Dichlorobenzylamine, This compound has unique chemical properties. The synthetic route is as follows., category: chlorides-buliding-blocks
Example 1: N-(3,4-dichlorobenzvl)-4-methvlpiperazine-l-carboxamideTo a solution of 3,4-dichlorobenzylamine (0.195 g, 1.11 mmol) and diisopropylethylamine(0.193 mL, 1.11 mmol) in 4 mL of THF was added a preformed solution of 4-nitrophenylchloroformate (0.223 g, 1.11 mmol) in 4 mL of THF. The reaction mixture was stirred at RTfor 3.5 h. To this solution was added N-methyl piperazine (0.442 g, 4.42 mmol) and theresulting solution was stirred at RT for 16h. The reaction mixture was concentrated underreduced pressure, diluted with EtOAc (50 mL) and the solution was washed with saturatedaqueous sodium bicarbonate (2 x 50 mL) and brine (50 mL). The solvent was removed underreduced pressure and the residue was subjected to supercritical fluid chromatography (21 mmx 150 mm diol-bonded SiC>2 (6|J,m particle size), isocratic method, 25percent MeOH (containing0.5percent isopropyl amine) in CO2) to afford the title compound as a pale yellow solid (0.245 g,73percent). MS m/z 302.2 (M+H)+; .H NMR (300.1 MHz, DMSO-d6) 52.17 (s, 3H), 2.22-2.26(m, 4H), 3.25-3.31 (m, 4H), 4.20 (d, J=5.8Hz, 2H), 7.12 (t, J=5.8Hz, 1H), 7.23 (dd, .7=8.2,2.0Hz, 1H), 7.47 (d, J=1.8Hz, 1H), 7.56 (d, /=8.2Hz, 1H).
According to the analysis of related databases, 102-49-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ASTRAZENECA AB; WO2006/14135; (2006); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics