Electric Literature of 13078-79-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 13078-79-0, name is 2-(3-Chlorophenyl)ethanamine belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Example 15 [2-(3-Chloro-phenyl)-ethyll-f4-(6-fluoro-lH-indol-4-yl)-6-morpholin-4-yI- p yrimidin-2-yIl -amine; A mixture of 6-fluoro-4-(2-methanesulfonyl-6-mophiholin-4-yl-pyrimidin-4-yl)- 1 H- indole (75 mg, 0.20 mmol) and 3-chlorophenethylamine (310 mg, 2.00 mmol) in DIPEA (0.1 mL, 0.57 mmol) and dioxane (0.4 mL) were heated in a microwave reactor at 150C for 40 minutes. The reaction mixture was purified by preparative HPLC to yield the title compound as an off-white solid (71 mg). deltaH (400MHz, CDCl3) 2.86 (t, J = 7.1, 2H), 3.58 (t, J = 4.5, 4H), 3.66 (q, J = 6.6, 2H), 3.73 ( t, J = 4.7, 4H), 4.90 (br s, IH), 6.29 (s,lH), 6.91 (s, IH), 7.06 (d, J = 8.2, 2H), 7.10-7.20 (m, 4H), 7.25 (d, J = 10.0, IH), 8.15 (br s, IH). [M + H]+ 452.10
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(3-Chlorophenyl)ethanamine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; PIRAMED LIMITED; THE INSTITUTE OF CANCER RESEARCH; WO2008/125839; (2008); A2;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics