Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2106-04-9, name is 3-Chloro-2-fluoroaniline, A new synthetic method of this compound is introduced below., Safety of 3-Chloro-2-fluoroaniline
Sodium nitrite (9.7 g, 0.14 mol) was dissolved in 25 mL of water and added to a solution of 3-chloro-2-fluoroaniline (20.0 g, 0.14 mmol) in trifluoroacetic acid cooled to -5C (100 mL). mL), Sodium azide (9.1 g, 0.14 mol) dissolved in 5 mL of water was added dropwise to the reaction solution, and the reaction mixture was stirred at 0 C. for 2 hours and quenched with water. Ethyl acetate extraction was performed. The phases were dried, filtered and concentrated to give 1-azide-3-chloro-2-fluorobenzene (18.7 g) as a brown oil which was used directly for the next reaction.
The synthetic route of 2106-04-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Sichuan Kelun Botai Bio-pharmaceutical Co., Ltd.; Liu Gang; Wu Yongyong; Yu Hua; Wang Kunjian; Li Xiaoyong; Sun Ling; Wang Runjiang; Chen Qiangqiang; Yang Long; Song Hongmei; Zeng Hong; Zhang Hong; Ye Qijun; Wang Lichun; Wang Jingyi; (98 pag.)CN107540659; (2018); A;,
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