Some common heterocyclic compound, 4090-55-5, name is 2-Chloro-5,5-dimethyl-1,3,2-dioxaphosphorinane 2-oxide, molecular formula is C5H10ClO3P, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 2-Chloro-5,5-dimethyl-1,3,2-dioxaphosphorinane 2-oxide
(2R,3R,4R, 5R)-5 -((((((2R,3R,4R, 5R)-5-(6-Benzamido-9H-purin-9-yl)-4-((tert- butyldimethylsilyl)oxy)-2-(hydroxymethyl)tetrahydrofuran-3 -yl)oxy)(2-cyanoethoxy)phosphoryl)oxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-2-(4-oxo-4, 5 -dihydro1 H-imidazo [4,5 -c]pyridin- 1 -yl)tetrahydrofuran-3 -yl hydrogen phosphonate (160 mg) was subjected to azeotropic dehydration with anhydrous pyridine, and anhydrous pyridine (3.0 mL) was added thereto. To the mixture was added 2-chloro-5,5-dimethyl-1,3,2- dioxaphosphinane 2-oxide (99 mg) at room temperature, and the mixture was stirred at room temperature for 1 hr. Water (96 1iL) and iodine (50.5 mg) were added thereto, and the mixture was stirred at room temperature for additional 20 mm. To the reaction mixture was added a mixture of sodium thiosulfate (190 mg) and water (0.4 mL), and the mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (methanol/ethyl acetate) to give the title compound (10.6 mg). MS: [M+H] 1044.3
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4090-55-5, its application will become more common.
Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; YOSHIKAWA, Masato; SAITOH, Morihisa; KATO, Taisuke; YOSHITOMI, Yayoi; SEKI, Tomohiro; NAKAGAWA, Yasuo; TOMINARI, Yusuke; SETO, Masaki; SASAKI, Yusuke; OKANIWA, Masanori; ODA, Tsuneo; SHIBUYA, Akito; HIDAKA, Kosuke; SHIOKAWA, Zenyu; MURATA, Shumpei; OKABE, Atsutoshi; NAKADA, Yoshihisa; MOCHIZUKI, Michiyo; FREEZE, Brian Scott; TAWARAISHI, Taisuke; WADA, Yasufumi; GREENSPAN, Paul D.; (423 pag.)WO2018/100558; (2018); A2;,
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