38762-41-3, name is 4-Bromo-2-chloroaniline, belongs to chlorides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. HPLC of Formula: C6H5BrClN
[00402] Synthesis of (4′-amino-3′-chlorobipheyl-4-yl)(4, 4-difluoropiperidin-l- yl)methanone (58): A mixture of 4-bromo-2-chlorobenzenamine (57; 2 g, 9.7 mmol), (4,4- difluoropiperidin-l-yl)(4-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)phenyl)methanone (4.1 g, 11.6 mmol), Pd(dppf)Cl2 (709 mg, 0.97 mmol), and K2C03 (2.7 g, 19.4 mmol) in 100 mL of dioxane and 10 mL of H20 was stirred at 100 C under nitrogen atmosphere for 2 h. The reaction mixture was cooled to room temperature and extracted with EtO Ac (100 mL X 3). The combined organic layers were washed with brine, dried over anhydrous Na2S04 and filtered, and the filtrate was concentrated under reduced pressure to give crude product, which was purified by silica gel chromatography (25% EtO Ac/petroleum ether) to yield 3.1 g of (4′-amino-3′-chlorobipheyl-4-yl)(4, 4-difluoropiperidin-l-yl)methanone (58) as a yellow solid (yield 91%). LCMS: m/z 351.1 [M+H]+, tR = 1.84 min.
The synthetic route of 38762-41-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; KARYOPHARM THERAPEUTICS INC.; BALOGLU, Erkan; SHACHAM, Sharon; SENAPEDIS, William; (155 pag.)WO2017/31204; (2017); A1;,
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