Electric Literature of 6223-78-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6223-78-5, name is 2,5-Dichloro-2,5-dimethylhexane belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
To a 1000 mL round-bottomed flask fitted with water condenser were added compound 1 (30.0 g, 165 mmol), toluene (35.1 mL, 330 mmol) and CH2Cl2 (150 mL). To this vigorously stirred solution was added aluminum chloride (1.92 g, 1.4 mmol) slowly in portionwise, which resulted in rapid evolution of gaseous hydrochloride acid. The reaction mixture was stirred at RT for 30min followed by additional aluminum chloride (400 mg). After the reaction mixture was stirred and heated to reflux for 15 min, it was cooled in an ice bath and quenched with 20% HCl aqueous solution (150mL). The mixture was extracted with hexanes; the combined organic layers were washed with water and brine, dried over anhydrous Na2SO4, filtered and concentrated in vacuo. The crude product was purified by column chromatography with hexanes to afford 2 as a white solid (28.3g, 85%), mp 34-35C (lit.2 34-36C). 1H NMR (CDCl3): delta 7.40 (d, J=8.0Hz, 1H), 7.31 (s, 1H), 7.14 (d, J=8.0Hz, 1H), 2.49 (s, 3H), 1.87 (s, 4H), 1.48(s, 6H), 1.47 (s, 6H).
The synthetic route of 2,5-Dichloro-2,5-dimethylhexane has been constantly updated, and we look forward to future research findings.
Reference:
Article; Wang, Min; Davis, Toni; Gao, Mingzhang; Zheng, Qi-Huang; Bioorganic and Medicinal Chemistry Letters; vol. 24; 7; (2014); p. 1742 – 1747;,
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