Reference of 106-39-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 106-39-8 as follows.
General procedure: In a thermostatted bath at 25C (or 60C for compounds 18 and 28), a 25 mL Schlenk flask was charged in air with a magnetic stir bar, arylbromide (0.5 mmol), arylboronic acid (0.6 mmol), K2CO3 (0.6 mmol), 1 (26.6 mg, 1mol-%), ethanol (1.5 mL), and water (0.5 mL). The reaction mixture was kept under vigorous stirring until the GC control showed no residual aryl bromide in solution. Water (10 mL) was added to the suspension and the organics were extracted with dichloromethane (3×10 mL). The solution was dried over Na2SO4 and then passed through a column filled with silica gel (diatomaceous earths were used in the case of compound 28). Elimination of the solvent under vacuum gave the desired biaryl as white microcrystalline solid. Purity (96÷99%) was established by GC and 1H NMR. 1H and 13C{1H} NMR data of compounds 8-28. Spin multiplicity is given by s=singlet, br s=broad singlet, q=quartet, st=septet, qq=quartet of quartets, ddd=doublet of doublets of doublets, m=unresolved multiplet. 4-Chloro-4′-methoxy-1,1′-biphenyl (17). Yield 94%. C13H11OCl (218.68): calcd. C 71.40, H 5.07; found C 71.27, H 5.13. 1H NMR (CDCl3): delta = 7.58-7.44 (4H, m), 7.42-7.33 (2H, m), 7.08-6.95 (2H, m), 3.86 (3H, s, OCH3) ppm. 13C NMR (CDCl3): delta = 159.3, 139.2, 132.6, 132.4, 128.8, 128.0, 127.9, 114.3, 55.3 (OCH3) ppm.
According to the analysis of related databases, 106-39-8, the application of this compound in the production field has become more and more popular.
Reference:
Article; Del Zotto, Alessandro; Colussi, Sara; Trovarelli, Alessandro; Inorganica Chimica Acta; vol. 470; (2018); p. 275 – 283;,
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