623-12-1, name is 1-Chloro-4-methoxybenzene, belongs to chlorides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. COA of Formula: C7H7ClO
A 10 mL Schlenk reaction tube was charged with 2 mol% (8.7 mg) of a trinuclear aza-carbene palladium compound I catalyst,Methoxychlorobenzene (0.20 mmol, 28.5 mg),1-naphthylboronic acid (0.30 mmol, 51.6 mg),Potassium tert-butoxide (0.40 mmol, 44.9 mg),Then add 2mL water as solvent,80 reaction 12h.Stop the reaction,extraction,Dry and concentrate,Thin layer chromatography,Dichloromethane / petroleum ether = 1/1 gave 36.5 mg of product,Separation yield 78%.
The synthetic route of 623-12-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Shangqiu Normal University; Wang Tao; Xu Kai; Liu Lantao; Zhao Wenxian; Liu Shuang; Li Feng; Meng Tuanjie; Xie Huanping; (12 pag.)CN105131044; (2017); B;,
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