Electric Literature of 53531-69-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 53531-69-4 as follows.
To a stirred mixture of potassium carbonate (74.8 g, 0.542 mol) in DCM (7OmL) andH20 (220 mL) at -10C was added pyrrolidine (21.2 g, 0.298 mol) in portions, and theresulting mixture was stirred for 20 mm. Then (4-bromophenyl)methanesulfonyl chloride (73.0 g,0.27 1 mol) in DCM (400 mL)was added drop-wise. The resultant mixture was stirred for lh at RT. The organic phase was separated, washed with H20, brine, dried over Na2SO4, and concentrated. The residue was recrystallized from 5% EtOAc/petroleum ether to give compound1-74. ?H NMR (300 MHz, CDC13) oe: 7.52 (d, 2H), 7.25 (d, 2H), 4.20 (s,2H), 3.20-3.30 (m, 4H),1.80-1.92 (m, 4H); LRMS found: 328 [M+23].
According to the analysis of related databases, 53531-69-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; MERCK SHARP & DOHME CORP.; CHILDERS, Matthew L.; DINSMORE, Christopher; FULLER, Peter H.; GUERIN, David J.; KATZ, Jason David; PU, Qinglin; SCOTT, Mark E.; THOMPSON, Christopher F.; ZHANG, Hongjun; CAI, Jiaqiang; DU, Xiaoxing; WANG, Chonggang; KONG, Norman; LIU, Yumei; WO2014/146246; (2014); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics