Related Products of 26487-67-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 26487-67-2 as follows.
1-(2-Chloroethyl)azepane hydrochloride (514 mg, 2.59 mmol), 50percent NaOH (10.4 mL,12.97 mmol), and a catalytic amount of benzyltriethylammonium chloride were added to a solution of (2-phenylimidazo[2, 1 -b][1 ,3,4]thiadiazol-6-yl)methanol (120 mg, 0.52 mmol) in toluene (3 mL) under argon atmosphere. The resulting mixture was refluxed for 6 h. The reaction mixture was diluted with water and extracted withEtOAc. The organic extracts were dried with Na2504 and evaporated to dryness. The crude product was purified by silica gel column chromatography (EtOAc:MeOH mixtures of increasing polarity as eluent) to afford the desired product (393 mg, 67percent). The product was converted into the corresponding maleate salt by adding maleic acid (27 mg, 0.23 mmol) in acetone (0.25 mL), followed by filtration of the resulting solid and drying under vacuum.1H-NMR (DMSO-d6, 300 MHz) & 9.24 (s, 1H), 8.27 (s, 1H), 7.94 (m, 2H), 7.62 (m,3H), 6.00 (s, 2H), 4.55 (s, 2H), 3.78 (t, J= 5.1 Hz, 2H), 3.31 (m, 6H), 1.76 (m, 4H),1.59(m, 4H)ppm.ESI(+)-HRMS: 357.1746 [M+H].
According to the analysis of related databases, 26487-67-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; LABORATORIOS DEL DR. ESTEVE, S.A.; ALCALDE-PAIS, Maria de las Ermitas; DIAZ-FERNANDEZ, Jose-Luis; MESQUIDA-ESTEVEZ, Maria, de les Neus; PALOMA-ROMEU, Laura; WO2014/6130; (2014); A1;,
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