Application of 1127-85-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1127-85-1 name is 2,4-Dichloro-5,6,7,8-tetrahydroquinazoline, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: A suspension of dichlorinated pyrimidinic fused ring obtained from general method B (1 mmol), corresponding aniline (1 .1 mmol) and diisopropylethylamine (5 mmol) in 2-propanol (2 ml) was stirred in a CEM microwave apparatus at 100-1 60 C (depending of corresponding aniline) until reaction completion or no crude evolution was observed. Then reaction crude was concentrated to dryness at low pressure, solved in dichloromethane (20 ml), extracted with NaHC03 saturated solution (20 ml), dried over Na2S04 and concentrated to dryness at low pressure. Final normal phase purification yielded titled compound.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2,4-Dichloro-5,6,7,8-tetrahydroquinazoline, and friends who are interested can also refer to it.
Reference:
Patent; FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA; ALMA MATER STUDIORUM – UNIVERSITA’ DI BOLOGNA; UNIVERSITA’ DEGLI STUDI DI PADOVA; DE VIVO, Marco; ORTEGA MARTINEZ, Jose Antonio; ARENCIBIA JIMENEZ, Jose Manuel; MINARINI, Anna; SISSI, Claudia; (86 pag.)WO2018/114700; (2018); A1;,
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