Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1008361-80-5, name is 4-Bromo-3-chlorobenzene-1,2-diamine, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 4-Bromo-3-chlorobenzene-1,2-diamine
Compound 14 was prepared following the procedure from Reddy and Reddy (Chem. Pharm. Bull 2010, 58, 953-956): a heterogeneous mixture of 4-bromo-3-chlorobenzene- 1,2-diamine (0.2 g) and (S)-lactic acid in 4N aq. HC1 (2 mL) was refluxed for 16 hours. The reaction mixture was then cooled to room temperature and neutralized with aq. ammonia. The resulting heterogeneous reaction mixture was extracted with EtOAc. The organic layer was dried (Na2S04) and concentrated. The residue was purified by column chromatography (silica gel, 0- 3.5 % MeOH in DCM) to afford the title compound as an orange yellow solid.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1008361-80-5.
Reference:
Patent; ACHILLION PHARMACEUTICALS, INC.; WILES, Jason, Allan; PHADKE, Avinash, S.; DESHPANDE, Milind; AGARWAL, Atul; CHEN, Dawei; GADHACHANDA, Venkat, Rao; HASHIMOTO, Akihiro; PAIS, Godwin; WANG, Qiuping; WANG, Xiangzhu; GREENLEE, William; (447 pag.)WO2017/35408; (2017); A1;,
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