Electric Literature of 932-96-7, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 932-96-7 as follows.
(a) 4-r(4-Chlorophenyl)(methyl)aminolbenzaldehvde; Toluene (100 mL) and 4-chloro-Lambda/-methylaniline (4.58 mL, 37.8 mmol) were added to a mixture of Cs2CO3 (17.26 g, 53 mmol), Pd(OAc)2 (0.42 g, 1.9 mmol), BINAP (1.77 g, 2.8 mmol) and 4-bromobenzaldehyde (7 g, 37.8 mmol). The mixture was stirred at 85 0C for 20 h and filtered through Celite. The solids were washed with EtOAc. The combined filtrates were concentrated and the residue purified by chromatography to give the sub-title compound. Yield: 7.7 g (82%).
According to the analysis of related databases, 932-96-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; BIOLIPOX AB; NILSSON, Peter; PELCMAN, Benjamin; KATKEVICS, Martins; WO2010/103279; (2010); A1;,
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