In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6223-78-5, name is 2,5-Dichloro-2,5-dimethylhexane belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Product Details of 6223-78-5
Into a 100-mL round-bottom flask, was placed methylbenzene (60 ml_), 2, 5- dichloro-2, 5-dimethylhexane (5 g, 27.30 mmol, 1.00 eq.). This was followed by the addition of AICI3 (2.7 g, 20.48 mmol, 0.75 eq.) in several portions at 0C. The resulting solution was stirred for 1 h at room temperature. The reaction mixture was cooled to 0 C. The reaction was then quenched by the addition of 30 ml_ of water. The resulting solution was extracted with 2×50 ml_ of ethyl acetate and the organic layers combined. The resulting mixture was washed with 1 x50 ml_ of brine and dried over anhydrous sodium sulfate and concentrated under vacuum. The residue was applied onto a silica gel column with EtOAc/petroleum ether (1/5). This resulted in 6.6 g (crude) of 1 , 1 ,4,4,6-pentamethyl-1 ,2,3,4-tetrahydronaphthalene as light yellow oil.
The synthetic route of 6223-78-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; DAWN SCIENTIFIC PHARMACEUTICALS, LLC; TSAI, Donald; KAELIN, David; (60 pag.)WO2019/169270; (2019); A1;,
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