Application of 6940-78-9,Some common heterocyclic compound, 6940-78-9, name is 1-Bromo-4-chlorobutane, molecular formula is C4H8BrCl, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
(b) Under a nitrogen atmosphere, 81.6 g (0.5 mol) of 7-hydroxy-1H-quinolin-2-one, 103 g (0.6 mol, 1.2 ep) of bromochlorobutane, and 103.5 g of potassium carbonate were added to the flask. Mol, 1.5 ep), 816 mL of acetone, stirred and heated at 60 C., and reacted for 8 hours.After the reaction is completed, cool down to 20C, filter, concentrate the filtrate to recover some acetone, and add water to the remaining residue.Solids were formed, stirred for 1 hour, filtered off with suction, washed with water, sucked dry, and dried in vacuum to obtain a crude product of compound (III) to obtain 110 g of compound (III) in a yield of 86%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Bromo-4-chlorobutane, its application will become more common.
Reference:
Patent; Zhejiang Liaoyuan Pharmaceutical Co., Ltd.; Song Zhigang; Yang Minhua; Cui Jianfeng; Chen Weijun; (16 pag.)CN106831739; (2017); A;,
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