In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 19393-92-1, name is 2-Bromo-1,3-dichlorobenzene belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Safety of 2-Bromo-1,3-dichlorobenzene
Intermediate 152 2′,6′-Dichloro-2,3-dimethoxybiphenyl: To a solution of 2,6-dichlorobromobenzene (5.0 g, 22 mmol) and sodium hydroxide (4.4 g, 0.11 mol) in DME-water (2:1, 180 mL) was added 2,3-dimethoxybenzene boronic acid (8.0 g, 44 mmol) at 90° C., followed by tetrakis(triphenyl-phosphine)palladium (0) (0.77 g, 0.66 mmol). The reaction mixture was heated at 90° C. overnight and cooled to room temperature. The mixture was extracted with methylene chloride and washed with water. The organic solvent was removed under vacuum. Chromatography with 5percent ethyl acetate in hexanes afforded 4.57 g (72percent) of the title compound as a white solid, mp: 49-50° C. MS EI m/e 282 M+.
The synthetic route of 19393-92-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Wyeth; US2006/241172; (2006); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics